{"id":1069,"date":"2016-08-15T13:05:53","date_gmt":"2016-08-15T13:05:53","guid":{"rendered":"http:\/\/ninecrows.com\/career\/?p=1069"},"modified":"2016-08-15T13:28:19","modified_gmt":"2016-08-15T13:28:19","slug":"using-resistance-to-probe-for-mechanism","status":"publish","type":"post","link":"https:\/\/ninecrows.com\/career\/2016\/08\/15\/using-resistance-to-probe-for-mechanism\/","title":{"rendered":"Using resistance to probe for mechanism&#8230;"},"content":{"rendered":"<p>A post in <a href=\"http:\/\/blogs.sciencemag.org\/pipeline\/\">Derek Lowe&#8217;s blog<\/a> pointed to an interesting technique for probing the mechanism by which a drug acts.<\/p>\n<p>These guys came up with a molecule that was effective against several diseases and then used selection pressures to breed a strain that was resistant in the laboratory. When they sequenced the genomes of the original and the resistant version, they looked for differences that would point to the drug&#8217;s target. Seems like a cool and effective way to let nature guide the investigation. As long as the resistant organism never leaves the lab you&#8217;ve got an effective drug and a good idea about why the drug works.<\/p>\n<p>http:\/\/blogs.sciencemag.org\/pipeline\/archives\/2016\/08\/15\/three-diseases-at-once<\/p>\n","protected":false},"excerpt":{"rendered":"<p>A post in Derek Lowe&#8217;s blog pointed to an interesting technique for probing the mechanism by which a drug acts. These guys came up with a molecule that was effective against several diseases and then used selection pressures to breed a strain that was resistant in the laboratory. When they sequenced the genomes of the &hellip; <a href=\"https:\/\/ninecrows.com\/career\/2016\/08\/15\/using-resistance-to-probe-for-mechanism\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Using resistance to probe for mechanism&#8230;<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[21,5],"tags":[],"class_list":["post-1069","post","type-post","status-publish","format-standard","hentry","category-on-the-web","category-thoughts"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p7F2Qc-hf","jetpack-related-posts":[],"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/posts\/1069"}],"collection":[{"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/comments?post=1069"}],"version-history":[{"count":2,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/posts\/1069\/revisions"}],"predecessor-version":[{"id":1071,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/posts\/1069\/revisions\/1071"}],"wp:attachment":[{"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/media?parent=1069"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/categories?post=1069"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ninecrows.com\/career\/wp-json\/wp\/v2\/tags?post=1069"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}